- Title
- Prenatal maternal stress and birth outcomes in rural Ghana: sex-specific associations
- Creator
- Ae-Ngibise, Kenneth Ayuurebobi; Wylie, Blair J.; Boamah-Kaali, Ellen; Jack, Darby W.; Oppong, Felix Boakye; Chillrud, Steven N.; Gyaase, Stephaney; Kaali, Seyram; Agyei, Oscar; Kinney, Patrick L.; Mujtaba, Mohammed; Wright, Rosalind J.; Asante, Kwalu Poku; Lee, Alison G.
- Relation
- BMC Pregnancy and Childbirth Vol. 19, no. 391
- Publisher Link
- http://dx.doi.org/10.1186/s12884-019-2535-9
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: In developed countries, prenatal maternal stress has been associated with poor fetal growth, however this has not been evaluated in rural sub-Saharan Africa. We evaluated the effect of prenatal maternal stress on fetal growth and birth outcomes in rural Ghana. Methods: Leveraging a prospective, rural Ghanaian birth cohort, we ascertained prenatal maternal negative life events, categorized scores as 0-2 (low stress; referent), 3-5 (moderate), and > 5 (high) among 353 pregnant women in the Kintampo North Municipality and Kintampo South District located within the middle belt of Ghana. We employed linear regression to determine associations between prenatal maternal stress and infant birth weight, head circumference, and length. We additionally examined associations between prenatal maternal stress and adverse birth outcome, including low birth weight, small for gestational age, or stillbirth. Effect modification by infant sex was examined. Results: In all children, high prenatal maternal stress was associated with reduced birth length (β = − 0.91, p = 0.04; p-value for trend = 0.04). Among girls, moderate and high prenatal maternal stress was associated with reduced birth weight (β = − 0.16, p = 0.02; β = − 0.18, p = 0.04 respectively; p-value for trend = 0.04) and head circumference (β = − 0.66, p = 0.05; β = − 1.02, p = 0.01 respectively; p-value for trend = 0.01). In girls, high prenatal stress increased odds of any adverse birth outcome (OR 2.41, 95% CI 1.01-5.75; p for interaction = 0.04). Sex-specific analyses did not demonstrate significant effects in boys. Conclusions: All infants, but especially girls, were vulnerable to effects of prenatal maternal stress on birth outcomes. Understanding risk factors for impaired fetal growth may help develop preventative public health strategies.
- Subject
- negative life events; prenatal maternal stress; birth anthropometrics; birth outcomes; sex-specific effects; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1455387
- Identifier
- uon:45078
- Identifier
- ISSN:1471-2393
- Rights
- © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Language
- eng
- Full Text
- Reviewed
- Hits: 6027
- Visitors: 6067
- Downloads: 146
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 519 KB | Adobe Acrobat PDF | View Details Download |